'Mega Crash' is a defensive maneuver that frees the character from the opponent while sacrificing a part of his or her life and two stocks of levels. 'Variable Aerial Rave' lets the character switch to his or her partner while in mid-air. There are also new universal techniques found in the game. Each character has a launcher to send the opponent to the air, allowing the character to do an 'Air Combo'.

'Hyper Variable Combination' lets characters of one team perform their Hyper moves, attacks that require a stock of level, at the same time, whereas 'Delayed Hyper Cancellation' cancels a current Hyper move of the character with another Hyper move of the character's partner. 'Snapback' is an attack that forces the opponent to switch characters should it land. Performing a 'Variable Counter' also lets the player tag out with another character. Characters can tag with another character, performing an attack upon entry called a 'Variable Attack'. Characters can call their partner to do a predefined 'Variable Assist' attack. Universal mechanics are similar to the previous Marvel vs. Additionally, most stages have a theme relating to a Tatsunoko franchise or a Capcom game and are mostly not interactive to the player. The camera has freedom to move in 3D at certain times during fights, for dramatic effect. series game to feature 3D graphics on a 2D plane creating a 2.5D environment consisting of character models and backgrounds rendered in 3D, while gameplay remains on a 2D plane used in traditional fighting games. The match is over once one of the teams have no remaining fighters. A team can perform two special moves simultaneously at the cost of three special bars. To regenerate health, each player may switch out their characters at any time.

The game's two largest and most powerful characters, Tatsunoko's Gold Lightan and Capcom's PTX-40A, fight on their own without a partner resulting in the inability to do universal techniques that require a partner. There is also the multifunctional 'Partner' button that can be used to tag in a teammate or provide assistance in attacking. games is the ability to execute special moves with simple commands. The game was built around a simplified three-button attack system (Weak, Medium, Strong) since it was developed with the Wii in mind and an attribute of Vs. Capcom is a departure from the more complex attack systems implemented in the Street Fighter series and some previous Vs. Capcom: Ultimate All-Stars is a 2.5D fighting game developed exclusively for the Wii console, in which players face each other with a team of two in a one-on-one fight to deplete their opponent's health bar.

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